Economos DeWolf Advances Life Sciences Corridor with $100M+ in San Clemente and Aliso Viejo Transactions

Economos DeWolf was engaged to market and sell 229 Avenida Fabricante, a flex/R&D property located in the coastal Orange County city of San Clemente. Prior to launching its campaign, the firm conducted deep research into the asset’s sole occupant: Glaukos Corporation, a publicly traded ophthalmic medical technology company at the forefront of treating chronic eye diseases.

Founded in 1998, Glaukos developed the first trabecular micro-bypass glaucoma stent and has since expanded across 17 countries. By the time of sale, Glaukos was well-established as a cornerstone of Orange County’s thriving life sciences ecosystem — which in 2024 employed over 60,986 people and generated $44.8 billion in regional economic output.

Positioning the building within this high-value context, Economos DeWolf created a narrative around healthcare innovation, biotech expansion, and R&D asset demand in Southern California. The strategic positioning contributed to a successful transaction, further reinforcing the firm’s leadership in Orange County’s specialized office, medical, and flex asset markets.

This deal adds to a broader portfolio of life sciences and commercial real estate sales in San Clemente and Aliso Viejo, where Economos DeWolf has closed over $100 million in transactions. With targeted CRE marketing, deep buyer engagement, and domain-specific insight, the firm continues to shape the built environment for Orange County’s innovation sectors.

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